• Tropical theileriosis is caused by the apicomplexan parasite

  2020-09-05

  

  Tropical theileriosis is caused by the apicomplexan parasite Theileria annulata which is transmitted by a tick vector from the genus Hyalomma in cattle (Echebli et al., 2014, Li et al., 2014). Theileria parasites invade the leukocytes by sporozoites secreted from the vector, schizonts mature into me

• Introduction Pain is frequently the first clinical symptom o

  2020-09-05

  

  Introduction Pain is frequently the first clinical symptom of head and neck carcinoma. Indeed, pain is the initial reason leading ∼70% of cancer patients to seek professional assistance (Lam & Schmidt, 2011; Rettig & D’Souza, 2015; Schmidt, 2014). Clinically, cancer-induced facial pain can be evoke

• br Conclusion br Conflict of

  2020-09-05

  

  Conclusion Conflict of interest Author contributions Acknowledgements Piyamas Kanokwongnuwut was supported by the Development and Promotion of Science and Technology Talent Project (DPST), Royal Thai Government Scholarship. Funding for the work was provided by the Attorney General’s Depa

• br As DAPK is dependent on Ca CaM

  2020-09-05

  

  As DAPK1 is dependent on Ca2+/CaM for its activity, its role in induction of autophagy is Ca2+-dependent and will be described in Section 5.1. LRRK1 and 2 were however shown to regulate autophagy in numerous studies where the role of Ca2+ was not investigated, and these mechanisms will be describe

• A variety of fused membered ring chemotypes have arisen

  2020-09-05

  

  A variety of fused 6–5-membered ring chemotypes have arisen such as 7-azaindole acetic acids, benzimidazolyl acetic acids, spiro-indolinone acetic acids, and indolizine acetic acids, however, to the best of our knowledge, fused 5,5-membered ring systems have not been reported. Prostaglandin D (PG

• Finally we have determined for the first

  2020-09-04

  

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent disability receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al., 200

• An important role for the precursor molecule of the

  2020-09-04

  

  An important role for the precursor molecule of the main EBI2 ligand, 25-OHC, in the inhibition of inflammation was recently shown. 25-OHC was demonstrated to inhibit inflammasome induction in mouse macrophages [28]. Inflammasome assemblies are the sites of caspase 1 activation and lead to the gener

• The synthesis of compounds a

  2020-09-04

  

  The synthesis of compounds 7a and 7b are outlined in Scheme 2. Compound 5 was obtained by di-tert-butyl pyrocarbonate protection of cannabinoid receptors 4a. Then, compounds 6a and 6b were obtained by amination of the fluoride with a morpholino and dimethylamine, respectively. Target compounds 7a a

• br Materials and methods br Results br Discussion

  2020-09-04

  

  Materials and methods Results Discussion The present study shows that 1) overexpression of wild-type or mutant α-SYN interferes with forskolin-induced DBH up-regulation, 2) α-SYN enters into the nucleus and is able to bind to CRE region, compete for CREB, and attenuate CRE-mediated transcri

• br Materials and methods br

  2020-09-04

  

  Materials and methods Results Discussion The first DGAT1 gene was described in the mouse in 1998 [28], and a few years later DGAT2 was identified from the oleaginous fungus Mortierella ramanniana[29]. Although both of them are known as the primary enzymes for de novo TAG biosynthesis, they

• Pattern separation is a process that

  2020-09-04

  

  Pattern separation is a process that takes place in the hippocampus and more specifically in the dentate gyrus (DG) and Cornu Ammonis region 3 (CA3) (Morris, Churchwell, Kesner, & Gilbert, 2012). The main source of input in the hippocampus is derived from the enthorinal cortex (EC) that mainly proje

• It is well established that

  2020-09-04

  

  It is well established that a number of intracellular signaling pathways mediate sensitization of sensory neurons (Gold and Gebhart, 2010, Richardson and Vasko, 2002). This redundancy could be advantageous since it provides diversity in initiating and maintaining hypersensitivity in response to inju

• However one major challenge will be

  2020-09-04

  

  However, one major challenge will be to understand how the diverse actions of D2Rs in multipartite, dopamine-sensitive circuits are coordinated to produce specific behaviors across species. It is possible that emerging techniques for imaging neuronal activity in different neuronal population in beha

• The proposed FDIR technique is presented in the following

  2020-09-03

  

  The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the DAPI hydrochloride environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estim

• The COMT gene maps to chromosome q Grossman

  2020-09-03

  

  The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT

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