• In the current study we compared

  2018-10-20

  

  In the current study, we compared two different genetic backgrounds on the induction and maintenance of multipotency by generating clonal iNSC lines from two distinct mouse strains (C57BL/6 vs. C3H). Clonal iNSC lines from distinct genetic backgrounds exhibited the distinct levels of conversion effi

• Stem cell factors and cancer development

  2018-10-20

  

  Stem cell factors and cancer development OCT4 OCT4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain class 5 transcription factor 1) belongs to the family of POU-domain transcription factors and is considered to be the key factor in maintaining and inducing pluripotency

• Similar to our in vitro results transplanted iNSCs

  2018-10-20

  

  Similar to our in vitro results, transplanted iNSCs exhibited in vivo-characteristics, transcriptome profiles, neural and metabolic programs similar to those of transplanted NSCs. In contrast to engrafted forebrain NSCs, however, transplanted iNSCs strongly expressed caudal regional marker genes and

• In the parenchymal niche found in

  2018-10-20

  

  In the parenchymal-niche found in the adult anterior lobe, SOX2-positive dihydrochloride were more densely connected to each other than in the MCL-niche, and formed dense cell clusters by E-cadherin (Fig. 1). We previously demonstrated that CAR and ephrin-B2 specifically localize at the apical cell

• Induction of EndMT results from integration of

  2018-10-20

  

  Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa

• harpagoside We herein show that simple supplementation with

  2018-10-20

  

  We herein show that simple supplementation with doxycycline greatly improves both hESC/iPSC viability and self-renewal. In practice, doxycycline dramatically enhances hESC/iPSC expandability, and the effects continue for long time periods. The effects of doxycycline are mediated by direct activation

• Many cellular mechanisms have the potential to contribute

  2018-10-20

  

  Many cellular mechanisms have the potential to contribute to enlarged carboxypeptidase a size and to faulty connections among centers in the brain that are thought to be linked to abnormal behaviors in ASD. While neurite outgrowth and pruning normally occur during the time period in which the accel

• Cip Kip proteins are expressed at higher levels in HSCs

  2018-10-20

  

  Cip/Kip proteins are expressed at higher levels in HSCs than in progenitor cells (Passegué et al., 2005). The role of p21Cip1 in HSCs is restricted to cell cycle regulation under stress conditions (van Os et al., 2007). p27Kip1 deficiency does not affect HSC numbers or HSC self-renewal, but alters t

• inos inhibitor Whole exome sequencing of tumor

  2018-10-20

  

  Whole-exome sequencing of tumor DNA from GBM 5 identified a total of 32 SNVs (Table S3). A subset of these SNVs was selected for single-cell analysis based on putative gene function and variant allele fractions encompassing high, low, and intermediate frequencies. The genomic targets selected includ

• On the path toward induced pluripotency

  2018-10-20

  

  On the path toward induced pluripotency, investigators rely on gene expression patterns as milestones to gauge appropriate progression, and comparative analysis of publically available gene expression profiles is a common approach. Clearly, our data show that inconsistencies in the relative levels o

• wnt signaling pathway Plasmid electroporation EP to the brai

  2018-10-20

  

  Plasmid electroporation (EP) to the wnt signaling pathway has become a commonly used method of in vivo transgenesis in development (Breunig et al., 2007; Saito and Nakatsuji, 2001). However, like most episomal methods of transgenesis, EP suffers from plasmid dilution (Chen and LoTurco, 2012). Thus,

• We generated an interactive fractal model

  2018-10-20

  

  We generated an interactive fractal model of mammary lobules based on parameters measured in histological sections. The fractal tree can be virtually sectioned at arbitrary depth and angle and then compared to breast tissue sections. This model can quantitate the number of branching generations, the

• br Materials and methods br Acknowledgments This work was

  2018-10-20

  

  Materials and methods Acknowledgments This work was supported by Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (grant numbers SAF2013-43005-R and SAF2016-76004-R). The authors thank INDEPF (Instituto de investigación y desarrollo social de enfermedades

• It is interesting that OB

  2018-10-20

  

  It is interesting that OB neurons produced from the transient Gli1-enriched subcallosal domain in juvenile mice mostly corresponded to sGCs, when they were derived from a region with active SHH signaling. It is possible that the relative levels of SHH signaling are adjusted in different domains. The

• ACA Another question is the heterogeneity within and between

  2018-10-20

  

  Another question is the heterogeneity within and between organoids, which seems common to all the protocols developed so far but has not yet been studied in detail. Several processes, such as progenitor proliferation, cell differentiation, and ontogenetic cell death, could be potential sources of or

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