• Baratta and colleagues screened LAL activity in

  2018-10-23

  

  Baratta and colleagues screened LAL activity in substantial numbers of NAFLD (n=240) and NASH (n=35) patients, as well as healthy subjects (n=100), using a modified, validated technique that employs dried blood spots (). The data show that NAFLD patients had significantly lower LAL activities than h

• In this issue Uckun et al take the concept

  2018-10-23

  

  In this issue, Uckun et al. take the concept of SMaRT-mediated repair back to its roots and explore its use in the repair of an oncogenic defect, CD22ΔE12, in childhood B-precursor leukemia (BPL), the largest subset of B-lineage acute lymphoblastic leukemia (ALL) (). BPL jasplakinolide express dysf

• Vaccine reverse engineering Burton focuses

  2018-10-23

  

  “Vaccine reverse engineering” (Burton, 2002) focuses on inferring the structure of improved immunogens based on interactions with neutralizing antibodies. While “epitope focused antigen design” (Correia et al., 2014) and other structural approaches (Kulp and Schief, 2013) show promise in identifying

• So how good is TILDA in

  2018-10-23

  

  So how good is TILDA in measuring HIV that is capable of replicating? The frequency of CD4+ T enba with inducible RNA by TILDA is within the realm of expectation. First, early treated individuals harbor fewer such cells than chronically treated individuals. Second, the size of inducible virus by TI

• Using an additive model integrated in

  2018-10-23

  

  Using an additive model integrated in the CaTS, we had 80% power for the overall dataset (961 cases and 3260 controls), assuming a minor disease allele frequency of 0.20, a genotypic relative risk for this variant of 1.31, a prevalence of neuropathic pain in the diabetic population of 0.25, and the

• br The determinants of amyloid deposition in the

  2018-10-23

  

  The determinants of amyloid deposition in the brain, increased intracerebral phosphorylated tau, hippocampal atrophy, and loss of synapses in areas of ARCA (the pathogenic determinants of most dementia) remain undetermined except for Mendelian genetic disorders and higher risk of both amyloid dep

• br Author Contributions br Conflicts of Interest br Acknowle

  2018-10-23

  

  Author Contributions Conflicts of Interest Acknowledgments Introduction ADAMs (a disintegrin and metalloproteinases) are multifunctional proteins involved in ectodomain shedding of transmembrane proteins and thereby regulate cell adhesion, migration, and cell–cell communication. Ectodoma

• br Efficacy In the study by

  2018-10-23

  

  Efficacy In the study by Haahr and colleagues, in the incontinent group, 5/6 patients underwent non-nerve sparing prostatectomy while in the continent group, 7/11 patients had some degree of nerve-sparing surgery. Thus, 8/17 patients in total had some degree of nerve sparing surgery, and 9/17 pat

• The following is the supplementary data related to this

  2018-10-23

  

  The following is the supplementary data related to this article. Authors\' Contributions Conflicts of Interests Acknowledgements This work was sponsored by the National Natural Science Foundation of China (81570603), the New-100 talent Plan of Shanghai Jiao Tong University School of Medici

• The following are the supplementary data related

  2018-10-23

  

  The following are the supplementary data related to this article. Potential conflicts of interest Author contributions Acknowledgements This work was supported by the Defense Advanced Research Projects Agency (DARPA) grant N66001-11-1-4180 and the Wyss Institute for Biologically Inspired E

• In the nearly years since the clevidipine investigational

  2018-10-23

  

  In the nearly 18years since the clevidipine investigational new drug application was filed, our understanding of the structure, tissue distribution and molecular biology of the l-type calcium channels (LTCC) has evolved dramatically (Zuccotti et al., 2011; Abernethy and Soldatov, 2002). The CaV-α-1

• The authors addressed this question using

  2018-10-23

  

  The authors addressed this question using a meta-analytic approach involving 15 studies that examined more than 12,000 smokers (). The study found that there were no differences in the benefits of quitting based on CHRNA5 allelic status. Consistent with many previous studies the benefits of quitting

• br Methods br Results A

  2018-10-23

  

  Methods Results A total of 7982 patients met criteria for inclusion. Non-responders were similar to responders except for younger age, lesser comorbidity and cardiac risk, and greater proportions of mood disorders and smoking (Appendix). In contrast, patients missing data were sicker than thos

• Due to the importance of ClfA as a virulence

  2018-10-23

  

  Due to the importance of ClfA as a virulence factor, the protein has been explored as a potential vaccine candidate. Recombinant ClfA induced an antibody response in mice (Josefsson et al., 2008) and mice immunized with ClfA presented with less severe arthritis compared to mice immunized with a cont

• Disclosures br Acknowledgements Research performed in

  2018-10-23

  

  Disclosures Acknowledgements Research performed in our laboratories is supported by the University of Franche-Comté, the Agence Nationale de Recherches sur le Sida et les Hepatites Virales (ANRS, n°13543 and 13544) and HIVERA 2013 (EURECA project). In this issue of , Venner and co-authors exp

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