• br Conclusions br Acknowledgments br Introduction To die or

  2025-03-03

  

  Conclusions Acknowledgments Introduction To die or not to die – that is the question. Christian de Duve created the word “autophagy” in 1960’s for the first time (Klionsky et al., 2016). The word “autophagy” was derived from the Greek roots “auto” (self) and “phagy” (eating) and referred to

• br Transparency document br Acknowledgments This work has be

  2025-03-01

  

  Transparency document Acknowledgments This work has been supported by the National Eye Institute (NIH) Grant 5R01EY023315-02 (MA). This study was also supported in part by National Center for Research Resources Grant S10RR027926 for the lipid analysis and by James and Jean Culver Vision Discov

• While increased arginase levels has been

  2025-03-01

  

  While increased arginase levels has been shown in animal models and in humans with cardiovascular dysfunction [16], [22], [23], it is unknown whether plasma levels or activity of Arginase may predict ED risk. In addition, recent evidence suggests that plasma l-arginine hydrolysis by arginases limits

• br Introduction Natural antioxidants in

  2025-03-01

  

  Introduction Natural antioxidants, in vegetables, have gained the attention of both researchers and consumers. Vegetable amaranth (Amaranthus tricolor) is a good source of minerals, vitamins, phenolics, and carotenoids; it also contains betalains, a nitrogen containing group of natural pigments,

• PGC mediated mitochondrial biogenesis in brown fat

  2025-03-01

  

  PGC-1α-mediated mitochondrial biogenesis in brown fat and endothelial endothelin receptor is in part regulated by eNOS and NO [28], [29]. Recent studies indicate that H2S not only augments NO bioavailability and signaling [11], [17], but provides protection against cardiac injury in an eNOS-depende

• With regard to participation of the S

  2025-03-01

  

  With regard to participation of the 12S-lipoxygenase in diabetes mellitus, inconsistent results have been obtained. Earlier studies demonstrated that the leukocyte-type 12S-lipoxygenase is specifically expressed in pancreatic b-cells and is involved in regulating glucose-stimulated insulin secretion

• Outro grupo de trabalho analisou pares

  2025-03-01

  

  Outro grupo de trabalho analisou 8.503 pares de gêmeos dinamarqueses de meia‐idade (SB431542 de cognição comparados com os que não sofreram qualquer intervenção, no entanto os autores consideram a diferença como um efeito de tamanho negligenciável. Na análise intrapares o gêmeo exposto à cirurgia ti

• br Conclusion br Acknowledgement This work was supported by

  2025-03-01

  

  Conclusion Acknowledgement This work was supported by JSPS KAKENHI (Grant Number 15K18770). Introduction Neural crest bestatin are multipotent progenitors in the vertebrate embryo that give rise to a vast array of different cell types including pigment cells, craniofacial skeleton and mes

• br Glioblastoma GBM is the

  2025-03-01

  

  Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of Selective 5-HT1 agonist tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination with

• Our studies suggest that AdipoR and AdipoR

  2025-03-01

  

  Our studies suggest that AdipoR1 and AdipoR2 genes are expressed in multiple tissues in the chicken wherein both receptors are likely to mediate the physiological effects of adiponectin. We determined the relative expression of AdipoR1 and AdipoR2 mRNA in various tissues and found that skeletal musc

• While the direct effects of ARI lead

  2025-02-28

  

  While the direct effects of 5-ARI lead to a dramatic cdc42 pathway in serum DHT levels, other laboratory values are also affected by 5-ARI use. Serum testosterone elevations are known to occur with both finasteride and dutasteride use, but values will typically remain within the normal laboratory r

• br Patients and Methods br Results br Discussion Gjerdrum et

  2025-02-28

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl SMER 3 is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et al also showed that dow

• br Research perspective In vitro and in

  2025-02-28

  

  Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron

• To maintain ATP levels postmortem

  2025-02-28

  

  To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield opioid receptors 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (Pinitiation of the experiment. We expected that if myosin ATPase is limi

• To further investigate the role of cholesterol in the Rh

  2025-02-28

  

  To further investigate the role of cholesterol in the Rh2-induced cytotoxicity, we then focused on the U937 cell line, which is cholesterol auxotroph and considered as a valuable model to study the importance of cholesterol in membrane structure and function (Billheimer et al., 1987), and used the e

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