• The role of DHT in early

  2023-03-07

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

• In the current study we provide evidence

  2023-03-07

  

  In the current study, we provide evidence that enhanced ATX activity correlates well with increased ATX protein concentration during cholestasis and pregnancy (Fig. 1). Hereby we have ruled out the possibility of ATX enzyme activation in these conditions, e.g. by circulating cholephiles. ATX clearan

• In the current study we provide evidence

  2023-03-07

  

  In the current study, we provide evidence that enhanced ATX activity correlates well with increased ATX protein concentration during cholestasis and pregnancy (Fig. 1). Hereby we have ruled out the possibility of ATX enzyme activation in these conditions, e.g. by circulating cholephiles. ATX clearan

• We demonstrate a role for low oxygen to

  2023-03-07

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 TAK-632 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA levels

• We demonstrate a role for low oxygen to

  2023-03-07

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 TAK-632 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA levels

• We demonstrate a role for low oxygen to

  2023-03-07

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 TAK-632 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA levels

• We demonstrate a role for low oxygen to

  2023-03-07

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 TAK-632 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA levels

• br Materials and methods br Results br Discussion

  2023-03-06

  

  Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o

• br Experimental section br Acknowledgments br Introduction A

  2023-03-06

  

  Experimental section Acknowledgments Introduction Adipose is a major endocrine organ which releases a range of bioactive agents [1]. Selected adipose depots have been established as sites of sex steroid metabolism [1]. Subcutaneous and visceral adipose express high levels of aromatase, cap

• farnesyl diphosphate synthase br Experimental and computatio

  2023-03-06

  

  Experimental and computation Standard samples of artemisinin (1) and artemether (2) were purchased from China National Institutes for Food and Drug Control. Their ECD spectra, at a concentration of 1.0–5.0mg/mL in ethanol, were recorded in a quartz cuvette of 1mm optical path length using a Jasco

• br Experimental section br Acknowledgment S B T is grateful

  2023-03-06

  

  Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont

• The increased occurrence of ARIA E in APOE carriers in

  2023-03-06

  

  The increased occurrence of ARIA-E in APOE ε4 carriers in phase 2 studies resulted in separate protocols for carriers and noncarriers in the subsequent phase 3 studies. Two 18-month trials comprising 1121 carriers and 1331 noncarriers with mild to moderate AD tested doses of bapineuzumab that varied

• p16 synthesis Women are usually at risk of sleep deprivation

  2023-03-06

  

  Women are usually at risk of sleep deprivation or restriction during pregnancy, especially in the third trimester of gestation, due to the pregnancy-associated anatomic, physiological and hormonal changes (Pien and Schwab, 2004). However, several major p16 synthesis developmental events, such as th

• A characteristic of iron present in brain fluids is

  2023-03-06

  

  A characteristic of iron present in brain fluids is considerable differences between measured values of ferritin and transferrin and the total iron content value (Table 1). Variation of the latter is compatible with differences in individual metabolisms. However differences between total iron conten

• The lactam emerged as lead candidate due

  2023-03-06

  

  The lactam (6) emerged as lead candidate due to its high selectivity, outstanding potency (against ALK or in clinically known ALK mutants), low in vitro clearance, and low efflux potential. The lactam (6) was selected for further profiling against the resistant ALK mutants. Preclinical rat pharmacok

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