• Although the exact mechanisms are not fully understood IGF

  2025-01-20

  

  Although the exact mechanisms are not fully understood, IGF-1 is tightly linked with ER and estrogen actions and a crosstalk occurs between these two systems in breast cancer. To illustrate this close relationship, studies have identified a synergy between IGF-1 and estrogen in human leukocyte elast

• CORT induced hippocampal damage has been implicated

  2025-01-20

  

  CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective

• An in vitro assay in which endothelial cells form D

  2025-01-20

  

  An in vitro assay in which endothelial cells form 3D tube-like structures was used to investigate effects of dNK on vessel stability. The results indicate that dNK cells from women with high spiral artery resistance index had reduced ability to activate endothelial cells, since endothelial cells pre

• Due to its unique histological architecture and blood

  2025-01-20

  

  Due to its unique histological architecture and blood supply, the lung is one of the most susceptible organs under uncontrolled systemic inflammatory circumstance [16]. Several studies have reported the anti-inflammatory benefits of metformin in acute lung injury induced by lipopolysaccharide (LPS),

• Evidence shows that glial activation increases the expressio

  2025-01-20

  

  Evidence shows that glial activation increases the expression of cytokines and chemokines in Parkinson's disease, which precede the degeneration of the substance nigra (Halliday and Stevens, 2011, Tansey and Goldberg, 2010). The use of non-steroidal anti-inflammatory drugs (except aspirin) can preve

• Within the thrombus there is

  2025-01-20

  

  Within the thrombus, there is heterogeneity in the activation of Thalassemia iron chelation based on the concentration gradients of soluble agonists emanating from the site of vascular injury, which has been excellently reviewed by Tomaiuolo et al.[1]. As part of the coagulation cascade, active thro

• Introduction Lipoxygenases LOXs are key enzymes that catalyz

  2025-01-20

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic Ro 48-8071 (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claesson, 2

• br Discussion In a series of linear mixed

  2025-01-20

  

  Discussion In a series of linear mixed effects models of longitudinal neuroanatomical change, we have identified genetic risk variants associated with an increase in Herbal laxative shape asymmetry in AD. The closest genes associated with significant SNPs include BIN1 (rs6733839), CD2AP (rs10948

• Within the PARP family TIPARP is most evolutionarily conserv

  2025-01-20

  

  Within the PARP family, TIPARP is most evolutionarily conserved with PARP12 (ARTD12) and PARP13 (ARTD13) [27,28,41]. All three proteins contain at least one RNA-type CCCH zinc finger domain, a poly-ADP-ribose binding WWE domain and a PARP catalytic domain (Fig. 1). PARP13 is catalytically inactive,

• To further clarify the vascular cell types expressing AR sub

  2025-01-20

  

  To further clarify the vascular cell types expressing AR subtypes, double immunofluorescence staining for ARs and vascular endothelial carbidopa​ or vascular smooth muscles was performed. As shown in Fig. 3, Fig. 4, overlay images show the expression of all ARs subtypes that we examined in vascular

• The literature suggests that adiponectin has a steroidogenic

  2025-01-20

  

  The literature suggests that adiponectin has a steroidogenic effect on ovarian function. In pigs, in vitro studies have shown that adiponectin reduced basal testosterone secretion in internal theca cells; in granulosa cells, it increased secretion of estradiol and, in combination with insulin, incre

• The A b action occurs in conditions where

  2025-01-20

  

  The A2b action occurs in conditions where high concentrations of adenosine is generated, so its blockage does not interfere with other physiological processes mediated by adenosine and others AR [105]. Furthermore the A3 receptor was shown to have pro-apoptotic effects on tumor lines of breast, lung

• In vitro studies with soman inhibited non aged AChE

  2025-01-18

  

  In vitro studies with soman-inhibited, non-aged AChE revealed a species dependent reactivating potency of HI-6 and MMB-4. With guinea pig AChE second order reactivation rate constants of 0.051 and 0.038mM−1min−1 were determined for HI-6 and MMB-4, respectively (Luo et al., 2007). Corresponding value

• br Materials and methods br Results

  2025-01-18

  

  Materials and methods Results Discussion CUs, which have been used as traditional medicine for thousands of years in East Asian countries, have the potential to be used for cancer chemoprevention and chemotherapy [17], [18], [19], [20]. CuB is one of the most promising agents as it is repor

• Functional enhancers are often composed of binding motifs of

  2025-01-18

  

  Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge

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